Clearly leprosy is a complex disease that is still significant in third world countries today. The fact that it is able to use Schwann cells, and skin macrophages as host cells, in order to replicate, adds to its significance as a disease to be reckoned with. The fact that the severity of the disease is dependent upon the body's immune response also adds to its significance, as it becomes hard to predict how a person will react once infected with the bacteria. It is also an important disease due to the fact that it is still not difinitively known how the disease spreads. It is most likely spread via droplets from the nose, and/or mouth of the infected person, however it transmission still cannot be solidly determined. Leprosy has also been a relevant disease since 1550 B.C, where the earliest documentation of the disease was found on papyrus scrolls from Egypt. Therefore, it has been a disease that has still yet to be eradicated, even after 3500 years of knowing about the disease. The disease may seem trivial in our society today, however in third world countries it is extremely prevalent, and needs the awareness of the general public in order to help educate, and treat people living with the disease. Over half of all leprosy cases are found to be in India, which is a staggering amount as we live in a society where vaccinations, and treatments are readily available. Often we take this medical care for granted and forget about those who suffer with debilitating diseases such as leprosy, and therefore light needs to be shed on the fact that there are still ancient diseases present in our modern society today that create a heavy impact on our world. Evidently leprosy is a notable significant disease that should be published, and have awareness spread about it, due to the vast reasons that have been outlined within this publishing.